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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A patient with HIV infection and a CD4+ T-cell count below 50 cells/µL develops a progressive neurological illness characterized by confusion, motor deficits, and seizures. Brain MRI reveals multiple white matter lesions without mass effect. PCR of the CSF is positive for JC virus. Thepathogenesis of this condition, progressive multifocal leukoencephalopathy (PML), involves:

A) Direct cytopathic effect of JC virus on neurons.
B) Inflammatory demyelination triggered by JC virus infection of astrocytes.
C) Lytic infection of oligodendrocytes by JC virus, leading to demyelination.
D) Opportunistic infection by JC virus due to impaired cell-mediated immunity.

2. The direct fluorescent antibody (DFA) test is commonly used for the rapid detection of which respiratory pathogen directly from nasopharyngeal specimens?

A) Legionella pneumophila (serogroup 1 in sputum)
B) Influenza virus
C) Bordetella pertussis
D) Mycoplasma pneumoniae

3. A microbiology laboratory receives a cerebrospinal fluid (CSF) sample from a patient with suspected meningitis. Gram stain shows numerous Gram-negative diplococci. The organism grows on chocolate agar but not on blood agar without added CO2. The MOST likely identification is:

A) Streptococcus pneumoniae
B) Neisseria meningitidis
C) Haemophilus influenzae
D) Listeria monocytogenes

4. A patient with a history of travel to an area endemic for schistosomiasis presents with hematuria. Microscopic examination of a urine sediment reveals a large oval egg with a prominent terminal spine. The MOST likely causative agent is:

A) Schistosoma mansoni
B) Schistosoma japonicum
C) Schistosoma haematobium
D) Schistosoma mekongi

5. During an outbreak of norovirus gastroenteritis in a nursing home, environmental swabs are collected to identify the source of the infection. Which of the following methods would be MOST appropriate for detecting norovirus in these samples?

A) Reverse transcription-polymerase chain reaction (RT-PCR)
B) Culture on human embryonic kidney (HEK) cells
C) Gram staining and microscopy
D) Enzyme-linked immunosorbent assay (ELISA) for viral antigens

Solutions: